Ebola: outbreak now second-largest on record, with new US entry rules

Source date: CDC page updated November 6, 2026; case counts as of November 4, 2026.

CDC reports 10,772 confirmed Bundibugyo-virus Ebola cases and 5,234 confirmed deaths across the Democratic Republic of the Congo, Kenya, Nigeria, Uganda, and France, and describes the outbreak as the second-largest Ebola outbreak on record. No US cases have been reported. CDC rates the risk to the American public and travelers as low.

Travelers who were in the DRC within 21 days of a flight are not permitted to board commercial flights to US destinations. From November 3, 2026 at 11:59 p.m. Eastern, all passengers on international flights to the United States must attest that they have not been in the DRC during the prior 21 days.

Why it matters: US hospitals, EMS agencies, and 911 centers are where screening, transport, and clinical decisions on any traveler with symptoms would happen, so the entry rules and CDC's clinical guidance affect those teams directly.

Primary source: CDC, Ebola Outbreak: Current Situation

Cold-chain monitoring systems targeted: US partners urge hardening

Source date: November 5, 2026.

CISA, with the FBI, HHS, USDA, and the Department of Transportation, states it is aware of malicious cyber activity targeting industrial refrigeration and cold-chain monitoring systems. The advisory names healthcare and public health, chemical, food and agriculture, and transportation sectors, including refrigerated transport. It lists possible effects including temperature changes, fire hazards, and inventory loss, and urges owners and operators to secure remote access to their operational technology.

Scope: The advisory is a national notice. It does not report incident counts or a geographic concentration.

Why it matters: The advisory names healthcare and public health among the sectors that use these systems, so hospital facilities and logistics staff are the audience for the hardening guidance.

Primary source: CISA, US Government Partners Urge Hardening Industrial Refrigeration and Cold Chain Monitoring Systems

Clade I mpox: presumed domestic spread in 16 jurisdictions

Source date: CDC page updated November 2, 2026.

CDC reports more than 160 laboratory-confirmed clade I mpox cases in at least 27 states and Puerto Rico since November 2024. Since August 2026, a growing share of US clade I cases have had no recent international travel or known links to a traveler. CDC reports presumed domestic transmission in 16 jurisdictions, describes a likely transition to sustained clade Ib transmission in the United States, and expects more domestically acquired cases. CDC rates the risk to most people as low.

Why it matters: Hospitals and public health teams need current surveillance and clinical guidance for suspected cases. CDC states that jurisdictions can contact poxvirus@cdc.gov for technical support and clinical consultation on severe cases, Monday to Friday, 8 a.m. to 5 p.m.

Primary source: CDC, Global Monkeypox: Current Situation

Andes hantavirus on an international cruise ship: 88 US contacts monitored

Source date: CDC MMWR published November 5, 2026. The outbreak was first reported to CDC on May 4, 2026, so this is a full report on an earlier event, not a new outbreak.

CDC reports seven cases of Andes virus infection, including three deaths, linked to a cruise ship that departed from Argentina. CDC and its partners identified and monitored 88 potentially exposed contacts across 27 US jurisdictions, including residents exposed on flights with a symptomatic passenger. No secondary Andes virus infections were identified among the monitored contacts.

Why it matters: The report documents contact monitoring across 27 jurisdictions for an exposure linked to an international cruise ship, which is the coordination problem health departments and receiving hospitals would face.

Primary source: CDC MMWR 75(43), Hantavirus Outbreak Caused by Andes Virus Linked to International Cruise Ship Travel